Oxidative stress reduces the yield of cell therapeutics in bioprocessing by about 10-15%, making them unnecessarily expensive to manufacture and less accessible to patients. Current mitigation methods, including antioxidant supplementation and cell reengineering, have significant limitations.
Xheme’s Polymer Composite Technology based single-use bioprocessing bags actively reduces oxidative stress, enabling enhanced cell viability, increasing yield, and maintaining the quality of the biologics being produced. A transformative technology, without the need for any major changes required to the existing manufacturing processes, for controlling oxidative stress in cell culture processes.
More and more manufacturers and consumers are turning to natural pigments instead of their synthetic counterparts. Microalgae are major producers of naturally derived commercial pigments, gaining higher value in the global food and cosmetics pigment markets as reduces carbon foot print significantly. But production can’t meet demand.
The Xheme technology either as a cell culture additive beads or as a single-use photo bioreactor could significantly improve the growth of microalgae and enhance the yield of chemicals produced thereof
Beginning in 2030, Diethylhexyl phthalate (DEHP), a PVC softening agent linked to cancers, male reproductive disorders, and delay in brain development will be banned in all medical devices such as blood bags in the Europe Union. US lawmakers have also called for action. However, currently available non-DEHP blood bags don’t meet the industry standard for stored blood for 42 days.
We have devised a solution featuring Xheme’s Polymer Composite Technology that eliminates the need for either DEHP or PVC and meets or exceeds the 42-day global storage standard and requires no major changes to the current manufacturing or storage processes. It enables blood bag manufacturers, hospitals, and doctors to save time and money using existing equipment and practices as the world prepares for this essential transition.
- Preserves the functional health of stored human blood, including rare blood types
- Prolongs storage of platelets at room temperature and can reduce microbial contamination (important for emergency and battlefield treatment)
- Allows for seamless integration with current blood bag manufacturing processes
Human milk is a crucial, living ecosystem rich in essential nutrients, live bacteria, immune cells, enzymes, lipids, and bioactive molecules that provide critical health benefits during infancy. However, oxidative damage and cell death during storage reduce its nutritional quality and limit its shelf life in the refrigerator. This rancidity not only leads to milk rejection by infants but also forces mothers to discard precious milk, impacting those who rely on pumped milk exclusively.
